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Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and so it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular may be the fact that as of right now there aren't long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heart rate, and must not be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high blood pressure level, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. 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